| Year |
FIRST / LAST |
| 1901 |
April 24: Three rainouts give Chicago the honor of hosting the FIRST game in American League history. Roy Patterson gets the win for the White Stockings over the Cleveland Blues 8-2. Clark Griffith manages the White Stockings. |
| 1901 |
April 25: Cleveland second baseman Erve Beck hits the FIRST home run in AL history off Chicago's John Skopec. |
| 1902 |
September 13: Tinker, Evers and Chance play their FIRST games at SS, 2B, and 1B for the Cubs. Twelve days earlier they appeared in the lineup together for the FIRST time, but Evers started at short and Tinker at third. |
| 1903 |
April 20: The New York Highlanders (later known as the Yankees) play their FIRST game, with Jack Chesbro losing 3-1 to Al Orth and Washington. |
| 1904 |
October 7: George Stovall hits his FIRST home run off his older brother Jesse who is playing his last game with Detroit. This marks the FIRST time one brother gives up a homer to another. This won't happen again until 1933. |
| 1905 |
August 30: Ty Cobb plays in his FIRST game and gets his first hit, a double off New York pitcher Jack Chesbro in a 5-3 Detroit win. Cobb has only 4,190 hits left in his bat. |
| 1907 |
August 2: The FIRST big league hit ever yielded by Walter Johnson was a bunt single by Ty Cobb. |
| 1907 |
August 7: Washington pitcher Walter Johnson records his FIRST major league victory with a 7-2 win over Cleveland. |
| 1910 |
April 14: William Taft is the FIRST President to throw out the first ball at a baseball opener in Washington. Walter Johnson catches it then pitches the 1st of his Opening Day Senators games. |
| 1911 |
April 15: Grover Cleveland Alexander pitches in his FIRST big league game. He loses 5-4 to the Braves. His arm will go on to win 373 games in his 20 year career. |
| 1911 |
September 22: Cy Young shuts out Pittsburgh 1-0 for his LAST career victory, win number 511 |
| 1911 |
October 6: Cy Young's LAST appearance in a major league game is a letdown, as he loses to Brooklyn 13-3. |
| 1912 |
April 12: The Tinker-Evans-Chance double play combination plays its LAST major league game together. Chance is replaced by Vic Saier. |
| 1912 |
June 20: Ernie Shore plays in his FIRST big league game. In his only appearance of the season, he takes the ball in the 9th inning with a 21-2 lead against the Braves. He allows 10 runs, 1 walk and 8 hits in the inning. Giants win 21-12. |
| 1913 |
April 10: In their FIRST official game as the Yankees (from Highlanders), New York loses on Opening Day, to the Senators and Walter Johnson 2-1. |
| 1914 |
June 9: Honus Wagner becomes the FIRST player to collect his 3,000 hit after 1900. |
| 1914 |
July 11: In his FIRST major league time at bat, Babe Ruth strikes out. However, on the mound he pitches the Red Sox to a 4-3 win. |
| 1915 |
Eddie Plank becomes the FIRST lefty to get 300 wins. |
| 1915 |
The Detroit Tigers were the LAST team to wear collars on their uniforms. |
| 1915 |
May 6: Babe Ruth launches his FIRST career home run off of Yankee pitcher Jack Warhop in the 3rd innings at New York's Polo Grounds. |
| 1916 |
May 14: Cardinals rookie Rogers Hornsby hits his FIRST home run, an inside the park job against the Brooklyn Dodgers. |
| 1916 |
August 26: Nap Lajoie plays in his LAST major league game. He goes 1 for 3 with a triple, with his last at bat being a fly out to right field. The A's win 5-0 as Joe Bush tosses a no hitter against Cleveland. |
| 1920 |
May 1: Babe Ruth hits his FIRST home run as a Yankee, hitting it off Red Sox pitcher Herb Pennock. |
| 1921 |
July 8: In Detroit, Harry Heilmann hits his FIRST career home run. |
| 1925 |
April 14: A's pitcher Lefty Grove makes his FIRST appearance in a major league game. The Red Sox run him out after he issues four straight walks in the fourth inning. A's great Mickey Cochrane appears in the this same game for his FIRST game. |
| 1925 |
May 1: The A's Jimmie Foxx, at age 17, pinch hits and singles in his FIRST major league at bat against the Senators. |